2226-5988 2686-6749 Клиническая и экспериментальная морфология Clinical and Experimental Morphology ООО "Группа МДВ" 10.31088/CEM2024.13.2.14-19 Патогенез и морфогенез хронического асептического остеомиелита Pathogenesis and morphogenesis of chronic nonbacterial osteomyelitis Доронина Полина Андреевна Доронина Полина Андреевна Doronina Polina A. cem.journal@mail.ru 0009-0004-4176-8793 Булгакова Варвара Викторовна Булгакова Варвара Викторовна Bulgakova Varvara V. cem.journal@mail.ru 0000-0002-4578-6874 Раденска-Лоповок Стефка Господинова Раденска-Лоповок Стефка Господинова Radenska-Lopovok Stefka G. radenska@mail.ru 0000-0002-4669-260X ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский университет), Москва, Россия I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia 24 06 2024 13 2 14 19 05 06 2023 20 11 2023 10 11 2023

Хронический абактериальный (рецидивирующий) остеомиелит – редкое аутовоспалительное заболевание опорно-двигательного аппарата неизвестной этиологии, описанное в 1972 году А. Гидеоном и соавторами как подострый или хронический симметричный остеомиелит. Представлен обзор литературы патогенеза этой болезни. Показаны нарушение баланса про- и противовоспалительных цитокинов и его связь с остеолизом. Дано собственное наблюдение некроза и истончения костных балок в сочетании со склерозом межбалочных пространств, а также выраженной лимфогистиоцитарной инфильтрации с большим количеством остеокластов. В связи с отсутствием патогномоничных признаков подчеркнута необходимость клинико-морфологических сопоставлений и генетического исследования в процессе дифференциальной диагностики.

Chronic nonbacterial (recurrent) osteomyelitis is a rare inflammatory disease of the musculoskeletal system with unknown etiology described in 1972 by A. Gidion et al. as subacute or chronic symmetrical osteomyelitis. This article reviews literature on pathogenesis and morphology of the disease and studies balance violation of pro- and anti-inflammatory cytokines and its association with osteolysis. Morphological manifestations in bone biopsies are given. We describe necrosis and thinning of trabeculae in combination with sclerosis of intertrabecular spaces and pronounced lymphohistiocytic infiltration with a large number of osteoclasts. Due to the absence of specific signs, the necessity of clinical and morphological correlations and genetic research in differential diagnosis is emphasized.

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