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  <front>
    <journal-meta>
      <journal-id journal-id-type="issn">2226-5988</journal-id>
      <journal-id journal-id-type="eissn">2686-6749</journal-id>
      <journal-title-group>
        <journal-title xml:lang="ru">Клиническая и экспериментальная морфология</journal-title>
        <journal-title xml:lang="en">Clinical and Experimental Morphology</journal-title>
      </journal-title-group>
      <publisher>
        <publisher-name>ООО "Группа МДВ"</publisher-name>
      </publisher>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.31088/CEM2024.13.4.86-91</article-id>
      <title-group>
        <article-title xml:lang="ru">Фиброэпителиальный стромальный полип вульвы с атипичными клетками, ассоциированный с беременностью</article-title>
        <trans-title-group xml:lang="en">
          <trans-title>Fibroepithelial stromal polyp of the vulva with atypical cells associated with pregnancy</trans-title>
        </trans-title-group>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author" corresp="yes">
          <name name-style="eastern">
            <surname>Казачков</surname>
            <given-names>Евгений Леонидович</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Казачков</surname>
              <given-names>Евгений Леонидович</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Kazachkov</surname>
              <given-names>Evgeniy L.</given-names>
            </name>
          </name-alternatives>
          <email>doctorkel@yandex.ru</email>
          <contrib-id contrib-id-type="orcid">0000-0002-2008-7671</contrib-id>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Лебедева</surname>
            <given-names>Марина Константиновна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Лебедева</surname>
              <given-names>Марина Константиновна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Lebedeva</surname>
              <given-names>Marina K.</given-names>
            </name>
          </name-alternatives>
          <email>cem.journal@mail.ru</email>
          <contrib-id contrib-id-type="orcid">0000-0002-5362-3549</contrib-id>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Гоголева</surname>
            <given-names>Дарья Витальевна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Гоголева</surname>
              <given-names>Дарья Витальевна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Gogoleva</surname>
              <given-names>Darya V.</given-names>
            </name>
          </name-alternatives>
          <email>cem.journal@mail.ru</email>
          <contrib-id contrib-id-type="orcid">0000-0001-5425-6472</contrib-id>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Сычугов</surname>
            <given-names>Глеб Вячеславович</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Сычугов</surname>
              <given-names>Глеб Вячеславович</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Sychugov</surname>
              <given-names>Gleb V.</given-names>
            </name>
          </name-alternatives>
          <email>cem.journal@mail.ru</email>
          <contrib-id contrib-id-type="orcid">0000-0003-3251-6944</contrib-id>
          <xref ref-type="aff" rid="aff1"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Казачкова</surname>
            <given-names>Элла Алексеевна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Казачкова</surname>
              <given-names>Элла Алексеевна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Kazachkova</surname>
              <given-names>Ella A.</given-names>
            </name>
          </name-alternatives>
          <email>cem.journal@mail.ru</email>
          <contrib-id contrib-id-type="orcid">0000-0002-1175-4479</contrib-id>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Медведева</surname>
            <given-names>Юлия Алексеевна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Медведева</surname>
              <given-names>Юлия Алексеевна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Medvedeva</surname>
              <given-names>Uliia A.</given-names>
            </name>
          </name-alternatives>
          <email>cem.journal@mail.ru</email>
          <contrib-id contrib-id-type="orcid">0009-0004-1088-9242</contrib-id>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <contrib contrib-type="author">
          <name name-style="eastern">
            <surname>Дуб</surname>
            <given-names>Анжела Алексеевна</given-names>
          </name>
          <name-alternatives>
            <name name-style="eastern" xml:lang="ru">
              <surname>Дуб</surname>
              <given-names>Анжела Алексеевна</given-names>
            </name>
            <name name-style="western" xml:lang="en">
              <surname>Dub</surname>
              <given-names>Anzhela A.</given-names>
            </name>
          </name-alternatives>
          <email>cem.journal@mail.ru</email>
          <contrib-id contrib-id-type="orcid">0000-0003-2007-3461</contrib-id>
          <xref ref-type="aff" rid="aff2"/>
        </contrib>
        <aff-alternatives id="aff1">
          <aff>
            <institution xml:lang="ru">ФГБОУ ВО Южно-Уральский государственный медицинский университет Минздрава России, Челябинск, Россия; ГБУЗ Челябинское областное патологоанатомическое бюро, Челябинск, Россия</institution>
          </aff>
          <aff>
            <institution xml:lang="en">South Ural State Medical University, Chelyabinsk, Russia; Chelyabinsk Regional Department of Pathology, Chelyabinsk, Russia</institution>
          </aff>
        </aff-alternatives>
        <aff-alternatives id="aff2">
          <aff>
            <institution xml:lang="ru">ФГБОУ ВО Южно-Уральский государственный медицинский университет Минздрава России, Челябинск, Россия</institution>
          </aff>
          <aff>
            <institution xml:lang="en">South Ural State Medical University, Chelyabinsk, Russia</institution>
          </aff>
        </aff-alternatives>
      </contrib-group>
      <pub-date pub-type="epub" iso-8601-date="2024-10-31">
        <day>31</day>
        <month>10</month>
        <year>2024</year>
      </pub-date>
      <volume>13</volume>
      <issue>4</issue>
      <fpage>86</fpage>
      <lpage>91</lpage>
      <history>
        <date date-type="received" iso-8601-date="2024-05-27">
          <day>27</day>
          <month>05</month>
          <year>2024</year>
        </date>
        <date date-type="accepted" iso-8601-date="2024-06-24">
          <day>24</day>
          <month>06</month>
          <year>2024</year>
        </date>
        <date date-type="rev-recd" iso-8601-date="2024-06-20">
          <day>20</day>
          <month>06</month>
          <year>2024</year>
        </date>
      </history>
      <abstract xml:lang="ru">
        <p>Приведено редкое наблюдение фиброэпителиального стромального полипа вульвы с атипичными клетками, развившегося у 43-летней женщины во время второй половины беременности и симулировавшего злокачественное новообразование. Подчеркивается опасность ошибочной интерпретации фиброэпителиального стромального полипа вульвы как злокачественной опухоли. Описаны подходы к иммуногистохимической диагностике фиброэпителиального стромального полипа вульвы. Показано, что для верификации этого новообразования необходимо иммуногистохимическое исследование с маркерами Кi67, Vimentin, panCytokeratin, S-100, CD34, Estrogen Receptor, Progesterone Receptor, SMA, Desmin, CD10. На доброкачественный характер поражения указывают анамнестические данные о появлении и развитии фиброэпителиального стромального полипа вульвы в период беременности, а также результаты иммуногистохимического исследования, демонстрирующие экспрессию рецепторов к женским половым гормонам в стромальных клетках. Подчеркивается необходимость динамического наблюдения за пациенткой для исключения местных признаков малигнизации в зоне хирургического вмешательства и своевременной диагностики рецидива.</p>
      </abstract>
      <trans-abstract xml:lang="en">
        <p>We present a rare observation of a fibroepithelial stromal polyp of the vulva with atypical cells which developed in a 43-year-old woman during the second half of pregnancy and simulated malignancy. The risk of misinterpreting а fibroepithelial stromal polyp of the vulva as a malignant tumor is emphasized. The article describes approaches to differential immunohistochemical diagnosis of a fibroepithelial stromal polyp of the vulva. It is shown that immunohistochemical study with markers Ki67, Vimentin, panCytokeratin, S-100, CD34, Estrogen Receptor, Progesterone Receptor, SMA, Desmin, and CD10 is necessary to verify this neoplasm. The benign nature of the lesion is indicated by data from a medical history on the appearance and development of a fibroepithelial stromal polyp of the vulva during pregnancy, as well as the results of immunohistochemical study demonstrating the expression of receptors to female sex hormones in stromal cells. We underscore the necessity of a follow-up of the patient over time to exclude local signs of malignization in the area of surgical intervention and timely diagnosis of recurrence.</p>
      </trans-abstract>
      <kwd-group xml:lang="ru">
        <title>Ключевые слова</title>
        <kwd>фиброэпителиальный стромальный полип вульвы</kwd>
        <kwd>беременность</kwd>
        <kwd>патологическая анатомия</kwd>
      </kwd-group>
      <kwd-group xml:lang="en">
        <title>Keywords</title>
        <kwd>fibroepithelial stromal polyp of the vulva</kwd>
        <kwd>pregnancy</kwd>
        <kwd>anatomic pathology</kwd>
      </kwd-group>
      <funding-group>
        <funding-statement xml:lang="ru">Исследование выполнено в рамках комплексной темы НИР Южно-Уральского государственного медицинского университета «Патоморфологическая характеристика, морфогенез и патоморфоз инфекционных и неинфекционных заболеваний человека и аспекты полиморбидности у населения Южного Урала» (№ 122090900047-6).</funding-statement>
        <funding-statement xml:lang="en">The study was carried out within the framework of the complex theme of the research work of South Ural State Medical University “Pathomorphological characterization, morphogenesis and pathomorphosis of infectious and non-infectious human diseases and aspects of polymorbidity in the population of the Southern Urals” (No. 122090900047-6).</funding-statement>
      </funding-group>
    </article-meta>
  </front>
  <body/>
  <back>
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</article>
